Blar i forfatter "Larsson, Per"

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    • Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial 

      Østergaard, Mikkel; Van Vollenhoven, Ronald F; Rudin, Anna; Hetland, Merete Lund; Schrumpf, Marte; Nordström, Dan C; Nurmohamed, Michael T; Gudbjornsson, Bjorn; Ørnbjerg, Lykke Midtbøll; Bøyesen, Pernille; Lend, Kristina; Hørslev-Petersen, Kim; Uhlig, Till; Sokka, Tuulikki; Grondal, Gerdur; Krabbe, Simon; Lindqvist, Joakim; Gjertsson, Inger; Glinatsi, Daniel; Kapetanovic, Meliha Crnkic; Aga, Anna-Birgitte; Faustini, Francesca; Parmanne, Pinja; Lorenzen, Tove; Giovanni, Cagnotto; Back, Johan; Hendricks, Oliver; Vedder, Daisy; Rannio, Tuomas; Grenholm, Emma; Ljoså, Maud-Kristine Aga; Brodin, Eli; Lindegaard, Hanne; Söderbergh, Annika; Rizk, Milad; Kastbom, Alf; Larsson, Per; Uhrenholt, Line; Just, Søren Andreas; Stevens, David John; Bay Laurbjerg, Trine; Bakland, Gunnstein; Olsen, Inge Christoffer; Haavardsholm, Espen A.; Lampa, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)
      Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action.<p> <p>Methods - Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate–severe disease activity ...

    • Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts 

      Dongre, Mitesh; Singh, Bhupender; Aung, Kyaw Min; Larsson, Per; Miftakhova, Regina; Persson, Karina; Askarian, Fatemeh; Johannessen, Mona; Hofsten, Jonas von; Persson, Jenny L.; Erhardt, Marc; Tuck, Simon; Uhlin, Bernt Eric; Wai, Sun Nyunt (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-07)
      Using <i>Caenorhabditis elegans</i> as an infection host model for <i>Vibrio cholerae</i> predator interactions, we discovered a bacterial cytotoxin, MakA, whose function as a virulence factor relies on secretion via the flagellum channel in a proton motive force-dependent manner. The MakA protein is expressed from the polycistronic <i>makDCBA</i> (<i>m</i>otility-<i>a</i>ssociated <i>k</i>illing ...